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| |
WT
|
F187Y
|
G191A
|
W232R
|
|---|
|
Active site pentad and surrounding residues
|
|
ARG314:PTR222s
|
97.78
|
98.26
|
97.97
|
98.82
|
|
CYS329:ARG314
|
98.46
|
98.33
|
98.38
|
98.12
|
|
LYS352:ASP353
|
60.41
| | | |
|
ILE355:LYS352
|
78.65
|
77.83
|
78.79
|
86.33
|
|
ARG410:ALA406
|
44.55
| | | |
|
ARG410:PTR222s
|
99.72
|
99.79
|
99.67
|
99.55
|
|
ARG410:ALA312
|
85.33
|
97.66
|
91.83
|
97.50
|
|
ARG410:CYS451
| |
41.72
| |
48.01
|
|
ALA414:ARG410
|
90.37
|
90.21
|
85.86
|
89.70
|
|
HIS453:ALA202s
|
85.22
|
82.20
|
82.39
|
80.23
|
|
HIS453:PTR222s
|
97.64
|
90.28
|
96.79
|
90.86
|
|
SER214s:HIS453
|
93.57
|
93.87
|
87.36
|
92.65
|
|
PTR222s:SER218s
|
76.09
|
65.74
|
66.94
|
67.68
|
|
Residues of point mutations and surrounding residues
|
|
PHE(Y)187:LYS198
|
99.05
|
99.37
|
99.40
|
99.53
|
|
GLY189:PHE(Y)187
| |
80.85
|
69.95
|
64.26
|
|
GLY197:PHE187
|
93.63
|
99.31
|
99.53
|
99.56
|
|
HIS193:GLY(A)191
| |
65.35
| |
65.47
|
|
TRP(R)242:LYS225
|
96.20
|
84.25
|
98.36
|
95.50
|
- Percentage of the hydrogen bonds established by the active site pentad with the surrounding residues (PTR stands for phosphotyrosine, while “s” following the residue number indicates that residue belongs to the small subunit)
