Apoptosis-like cell death upon kinetoplastid induction by compounds isolated from the brown algae Dictyota spiralis

Table 1 Summary of in vitro leishmanicidal, trypanocidal and cytotoxic activity of compounds 1–3 isolated from the crude extract of Dictyota spiralis, and the Selectivity Index, compared to the positive controls miltefosine and benznidazole

Compound	CC₅₀: murine macrophages (μM)	Leishmania amazonensis			Trypanosoma cruzi
Compound	CC₅₀: murine macrophages (μM)	IC₅₀: promastigote (µM)	IC₅₀: amastigote (μM)	Selectivity index	IC₅₀: epimastigote (μM)
1	36.96 ± 2.74a	18.89 ± 5.28b	0.97 ± 0.13a	37.76	13.11 ± 3.62b
2	52.05 ± 6.63b	18.95 ± 0.42b	2.03 ± 0.22b	25.56	18.32 ± 0.91c
3	69.98 ± 0.13c	36.81 ± 5.19c	3.88 ± 0.17c	18.02	35.28 ± 4.09d
Miltefosine (positive control for Leishmania amazonensis)	72.18c	6.47 ± 0.58a	3.11c	23.16	–
Benznidazole (positive control for Trypanosoma cruzi )	400d	–	–	–	6.95a

Values in table are presented as the mean ± standard deviation (SD). Means within compounds (rows) with different lowercase letters (a–d) are significantly different (P < 0.05) for each test
IC₅₀, Inhibitory concentration that inhibits 50% of the growth of the tested parasite; CC₅₀, cytotoxic concentration that reduces 50% of the murine macrophages’ viability; Selectivity Index (SI), CC₅₀/IC₅₀)

ISSN: 1756-3305