Table 5 Occurrence of pathological changes in organs and organ tissues of females from experimental groups.
From: Impact of Babesia microti infection on the initiation and course of pregnancy in BALB/c mice
| Organ type | Pathological changes | Group A | Group B | Group C | Group D | Control group PU | Control group NPU | Statistical values | p value |
|---|---|---|---|---|---|---|---|---|---|
| Spleen | Extramedullary haematopoiesis | 83% (5/6) | 83% (5/6) | 59% (10/17) | 93% (14/15) | 100% (4/4) | 75% (3/4) | NS | p > 0.05 |
| Lymphoid hyperplasia | 50% (3/6) | 50% (3/6) | 76% (13/17) | 40% (6/15) | 50% (2/4) | 50% (2/4) | NS | p > 0.05 | |
| Presence of siderophages | 50% (3/6) | 83% (5/6) | 6% (1/17) | 47% (7/15) | 0% (0/4) | 50% (2/4) | χ2 = 17.32, df = 5 | p < 0.05 | |
| Congestion | 0% (0/6) | 0% (0/6) | 18% (3/17) | 7% (1/15) | 0% (0/4) | 0% (0/4) | NS | p > 0.05 | |
| Liver | Inflammation | 100% (6/6) | 83% (5/6) | 100% (6/6) | 93% (14/15) | 100% (5/5) | 75% (3/4) | NS | p > 0.05 |
| Degeneration of the hepatocytes | 0% (0/6) | 33% (2/6) | 0% (0/17) | 47% (7/15) | 0% (0/5) | 0% (0/4) | NS | p > 0.05 | |
| Hyperaemia | 0% (0/6) | 67% (4/6) | 6% (1/17) | 47% (7/15) | 80% (4/5) | 50% (2/4) | χ2 = 21.40, df = 5 | p < 0.05 | |
| Necrosis of the hepatocytes | 50% (3/6) | 0% (0/6) | 24% (4/17) | 53% (8/15) | 20% (1/5) | 25% (1/4) | NS | p > 0.05 | |
| Cholestasis in hepatocytes | 0% (0/6) | 83% (5/6) | 12% (2/17) | 13% (2/15) | 0% (0/5) | 50% (2/4) | χ2 = 27.72, df = 5 | p < 0.001 | |
| Kidneys | Necrosis of rental tubules | 83% (5/6) | 100% (6/6) | 94% (16/17) | 87% (13/15) | 67% (4/6) | 100% (4/4) | NS | p > 0.05 |
| Haemoglobin in renal tubule cells | 0% (0/6) | 17% (1/6) | 12% (2/17 | 20% (3/15) | 0% (0/6) | 25% (1/4) | NS | p > 0.05 | |
| Acute nephritis | 0% (0/6) | 33% (2/6) | 0% (0/17) | 0% (0/15) | 0% (0/6) | 0% (0/4) | NS | p > 0.05 | |
| Glomerulonephritis | 33% (2/6) | 0% (0/6) | 6% (1/17)) | 0% (0/15) | 17% (1/6) | 25% (1/4) | NS | p > 0.05 | |
| Blood haemorrhages | 0% (0/6) | 17% (1/6) | 0% (0/17) | 27% (4/15) | 33% (2/6) | 0% (0/4) | NS | p > 0.05 | |
| Hyperaemia | 17% (1/6) | 50% (3/6) | 24% (4/17) | 40% (6/15) | 67% (4/6) | 0% (0/4) | NS | p > 0.05 | |
| Proteinuria | 0% (0/6) | 0% (0/6) | 12% (2/17) | 0% (0/15) | 0% (0/6) | 0% (0/4) | NS | p > 0.05 | |
| Parenchymatous degeneration of rental tubules cells | 33% (2/6) | 67% (4/6) | 76% (13/17) | 80% (12/15) | 100% (6/6) | 0% (0/4) | χ2= 18.43, df = 5 | p < 0.05 | |
| Brain | Cerebral oedema | 83% (5/6) | 83% (5/6) | 69% (11/16) | 77% (10/13) | 100% (6/6) | 50% (2/4) | χ2= 11.47, df = 5 | p < 0.05 |
| Neuronophagia | 33% (2/6) | 0% (0/6) | 50% (8/16) | 0% (0/13) | 50% (3/6) | 50% (2/4) | χ2= 18.11, df = 5 | p < 0.05 | |
| Nerve cell (neuron) necrosis | 33% (2/6) | 67% (4/6) | 56% (9/16) | 69% (9/13) | 50% (3/6) | 50% (2/4) | NS | p > 0.05 | |
| Nerve cells degeneration | 33% (2/6) | 17% (1/6) | 6% (1/16) | 46% (6/13) | 0% (0/6) | 25% (1/4) | χ2= 16.08, df = 5 | p < 0.05 | |
| Hyperaemia | 0% (0/6) | 33% (2/6) | 0% (0/16) | 0% (0/13) | 33% (2/6) | 0% (0/4) | NS | p > 0.05 | |
| Proliferation of microglia | 0% (0/6) | 0% (0/6) | 13% (2/16) | 15% (2/13) | 0% (0/6) | 25% (1/4) | NS | p > 0.05 | |
| Inflammation | 0% (0/6) | 0% (0/6) | 6% (1/16) | 0% (0/13) | 0% (0/6) | 0% (0/4) | NS | p > 0.05 | |
| Heart | Necrosis of cardiomyocytes | 67% (4/6) | 17% (1/6) | 76% (13/17) | 20% (3/15) | 33% (2/6) | 50% (2/4) | χ2= 14.77, df = 5 | p < 0.05 |
| Inflammation of the heart muscle | 50% (3/6) | 33% (2/6) | 41% (7/17) | 27% (4/15) | 50% (3/6) | 25% (1/4) | NS | p > 0.05 | |
| Focal fibrosis of myocardium | 0% (0/6) | 0% (0/6) | 6% (1/17) | 0% (0/15) | 0% (0/6) | 0% (0/4) | NS | p > 0.05 | |
| Congestion of the heart muscle | 0% (0/6) | 50% (3/6) | 6% (1/17) | 20% (3/15) | 83% (5/6) | 0% (0/4) | χ2 = 20.87, df = 5 | p < 0.05 | |
| Atrophy of myocardium | 0% (0/6) | 0% (0/6) | 18% (3/17) | 0% (0/15) | 0% (0/6) | 25% (1/4) | NS | p > 0.05 | |
| Hyaline degeneration myocardium | 0% (0/6) | 0% (0/6) | 12% (2/17) | 0% (0/15) | 0% (0/6) | 0% (0/4) | NS | p > 0.05 | |
| Lungs | Atelectasis | 50% (3/6) | 100% (6/6 | 76% (13/17) | 73% (11/15) | 100% (6/6) | 0% (0/4) | χ2 = 29.08, df = 5 | p < 0.001 |
| Oedema | 0% (0/6) | 0% (0/6) | 6% (1/17) | 0% (0/15) | 0% (0/6) | 0% (0/4) | NS | p > 0.05 | |
| Emphysema | 100% (6/6) | 67% (4/6) | 53% (9/17) | 40% (6/15) | 83% (5/6) | 100% (4/4) | χ2 = 14.45, df = 5 | p < 0.05 | |
| Congestion | 0% (0/6) | 50% (3/6) | 29% (5/17) | 20% (3/15) | 67% (4/6) | 25% (1/4) | NS | p > 0.05 | |
| Necrosis | 17% (1/6) | 0% (0/6) | 0% (0/17) | 7% (1/15) | 0% (0/6) | 0% (0/4) | NS | p > 0.05 | |
| Siderophages | 0% (0/6) | 17% (1/6) | 6% (1/17) | 0% (0/15) | 17% (1/6) | 0% (0/4) | NS | p > 0.05 | |
| Pneumonitis, acute interstitial inflammation | 0% (0/6) | 17% (1/6) | 94% (16/17) | 40% (6/15) | 67% (4/6) | 0% (0/4) | NS | p > 0.05 | |
| Uterus | Blood haemorrhages in wall and mucous membrane | 0% (0/3) | 0% (0/6) | 0% (0/16) | 36% (5/14) | 25% (1/4) | 0% (0/4) | NS | p > 0.05 |
| Hyperaemia of wall and mucous membrane | 0% (0/3) | 50% (3/6) | 0% (0/16) | 21% (3/14) | 25% (1/4) | 0% (0/4) | χ2 = 13.29, df = 5 | p < 0.05 | |
| Inflammation of the mucous membrane | 0% (0/3) | 50% (3/6) | 69% (11/16) | 43% (6/14) | 25% (1/4) | 25% (1/4) | NS | p > 0.05 | |
| Necrosis | 0% (0/3) | 0% (0/6) | 0% (0/16) | 7% (1/14) | 0% (0/4) | 0% (0/4) | NS | p > 0.05 | |
| Siderophages in myometrium | 0% (0/3) | 33% (2/6) | 6% (1/16) | 0% (0/14) | 0% (0/4) | 0% (0/4) | NS | p > 0.05 | |
| Oedema of mucous membrane | 0% (0/3) | 0% (0/6) | 0% (0/16) | 7% (1/14) | 0% (0/4) | 0% (0/4) | NS | p > 0.05 |